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20 Jul 2010Vitamin C can help combat cancer

While the health benefits of vitamin C have been known for some time, new research has revealed that it can help curb the growth of cancer cells.

The study, coming from the University of Otago in Christchurch, offers the first real evidence of a connection between vitamin C and tumour growth.

The results offer a promising and simple intervention to help in the fight against cancer, at the level of both prevention and cure, according to study leader, Associate Professor Margreet Vissers of the University’s Free Radical Research Group.

“The role of vitamin C in cancer treatment has been the subject of debate for years, with many anecdotal accounts of the beneficial role of vitamin C in both the prevention and treatment of cancer,” Associate Professor Vissers said.

Her previous research had demonstrated the vitamin’s importance in maintaining cell health and hinted at its potential for limiting diseases such as cancer.

Her latest study looked at whether vitamin C levels were lowered in patients with endometrial tumours.

It investigated whether the cancer cells had low vitamin C levels and whether this correlated with tumour aggressiveness and resistance to chemotherapy. Associate Professor Vissers and her colleagues found tumours were less able to accumulate vitamin C compared with normal healthy tissue, and that this related to the ability of the tumour to survive and grow.

Tumours with low vitamin C levels had more of a protein called HIF-1 which allows them to thrive in conditions of stress.

The findings are significant as they show, for the first time, a direct relationship between HIF-1 and vitamin C levels in tumours and suggest it would be beneficial for people with cancer cells to have more vitamin C.

This could help limit the rate of tumour growth, increase the responsiveness to chemotherapy and may prevent the formation of solid tumours.

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